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The word detox is thrown around a lot in relation to clean living and eating but generally what meaning do we take from that? The implied meaning refers to weight loss, glowing skin, renewed energy, shiny eyes and a renewed joie-de-vivre. It seems to promise a new you, a new beginning and perhaps a new journey. However out of reach this may appear, there is some truth in this promise. Traditionally a detox period comes with the change of the seasons. Cleansing has a rich tradition throughout all ages and cultures. It has been part of cultural rituals in some areas of the world for thousands of years. There is even biblical references referring to dietary restrictions, physical and aromatic cleansing. This is mirrored in diverse cultures across the world from Native Americans to Ancient Greece, Roman and even Norse times. There are some unifying concepts across the cultures that aim to stimulate the body’s natural detoxification pathways as well as ‘cleansing the soul’.
Throughout time and ages, equinox has been celebrated and marked with cleansing regimes and the ultimate cathartic clear out in our life. It is thought this is the best time to do this to welcome greater energies and spiritual freedom but there is also a more practical base to this way of thinking.
So the idea of detoxification, resounds with our deepest soul and patronage and is not surprising that we feel attuned to the idea of physical and soulful cleansing. However, as with most traditions, there is usually some scientific reasoning for these accrued ritualistic practices devised by human nature and here I attempt to demystify and bring clarity to the cleanse!
Detoxification, biochemically, defines the process by which harmful compounds, such as drugs or poisons, are converted to less toxic compounds in the body for excretion. Let’s take a step back – what on earth would our body need to detoxify, what are these poisons of which we speak? Here’s a brief list:
If you stop for a minute and list all of the chemicals that you come into contact with, which aren’t directly from nature, the truth can be quite shocking.
The Environmental Working Group conducted a survey of more than 2300 people and concluded that on average an individual is exposed to 126 unique chemical ingredients from an average of 9 personal care products[i]. Of these 1 of every 5 adults are potentially exposed daily to all of the top 7 carcinogenic impurities common to personal care products – hydroquinone, ethylene dioxide, 1,4-dioxane, formaldehyde, nitrosamines, PAHs and acrylamide. The statistics for women are even more shocking with an average exposure of up to 168 ingredients from 12 products[ii]. And this is only the point of the dagger, the exposure continues via cleaning products around the home, fragrances, exhaust fumes, burnt and overcooked food, pesticides, plastic wrap and so it goes on. You can see how this list could easily slide up into the 100s and 1000s.
However, considering all of this, we are still alive, we are still functioning and we can still carry on wading through this onslaught of toxicity. How so? Well, we have a very complicated and fine-tuned system of detoxifying these poisons from our body – this is for the most part via the liver, then also other organs are involved such as skin, kidney, spleen and intestines.
The liver has a phenomenal capacity to convert lipophiles (fat loving molecules) into more water soluble metabolites which can be efficiently eliminated from the body. It has developed a complex system to do this which we refer to as phase 1, phase 2 and sometimes phase 3 detoxification. However as you can imagine the liver needs a good pool of resources to help it to do this and to carry out these thousands of processes. This is mostly by way of nutrients provided through food (essential), and some which the body can manufacture itself (non-essential). The picture here is starting to unravel. Put yourself in the situation where you are living in an urban area, with a stressful job and commute, your food is less than ideal as you buy a pre-packaged ‘healthy’ option from your local store on your way home and wash it down with a glass of wine or 2, then add on another layer of genetic idiosyncrasies which may increase or decrease certain enzyme activity resulting in less effective detoxification, then it is apparent that this person’s toxic load is already brimming, so where are all those essential nutrients going to come from so that his liver can do his daily sweep up? Well the liver learns to cut corners (it will always do the route which requires the least energy) and it will use up any reserves this stressed individual has left. Now add on years and decades of the same and perhaps you can see how despite our liver’s ability to plug away at its job, a little gentle support and nurturing would not go amiss!
Here are some signs and symptoms of a sluggish and/or struggling liver:
The good news is, that the liver is the only organ that can regenerate itself given the right support. So how should we support our liver and offer it a gentle hug in appreciation?
One particular process which has been assaulted at this time of year is our sulphation capabilities. Sulphation is responsible for detoxing alcohols, hormones, xenobiotics and bacterial toxins. If you have access to your DNA data then this may be effected by the expression of the SULT and SUOX genes. If polymorphisms exist on these genes, then sulphation support would be particularly helpful to relieve any clinical symptoms listed above.
Nutrients to support sulphation and other detoxification pathways for phase i and ii include:
For a healthy and happy liver our main advice would be to heed this advice on an 80/20 basis all year round:
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[iii] Johnson et al. Molybdenum cofactor deficiency in a patient previously characterized as deficient in sulfite oxidase. Biochem Med Metabol Biol. 1988; 40: 86-93.
[iv] Swarnalatha et al. Oxidative stress in hemodialysis patients receiving intravenous iron therapy and the role of N-acteylcysteine in preventing oxidative stress. Saudi J Kidney Dis Transpl. 2010; 21: 852-8.
[v] Ben-Ari Z, Vaknin H, Tur-Kaspa R. N-acetylcysteine in acute hepatic failure (non-paracetamol-induced). Hepatogastroenterology 2000;47:786–9.
[vi] Reed GA, et al. A phase I study of indole-3-carbinol in women: tolerability and
effects. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1953-60.
[vii] Michnovicz et al. Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans. J Natl Cancer Inst 1997;89(10):718-23.
[viii] Auborn et al. Indole-3-carbinol is a negative regulator of estrogen. J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S
[ix] Kunimasa et al. Biosci Biotechnol Biochem. 2008 Aug;72(8):2243-6. Epub 2008 Aug 7.
Indole-3-carbinol suppresses tumor-induced angiogenesis by inhibiting tube formation and inducing apoptosis.
[x] Heber D, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014 Jan;5(1):35-41.
[xi]Chaudhary A, et al. Free radical scavenging, antiproliferative activities and profiling of variations in the level of
phytochemicals in different parts of broccoli (Brassica oleracea italica). Food Chem. 2014 Apr 1;148:373-80.
[xii] Park EJ, Pessuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231-55.
[xiii] Nestle M. Broccoli sprouts in cancer prevention. Nutr Rev 1998;56:127-30
[xiv] Zhang Y, Callaway EC. High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J. 2002; 364: 301-7
[xv] Li et al. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clinical Cancer Research 2010 16 (9): 2580–2590.
[xvi] Hwang Jm et al, 2010.
[xvii] Constantinou A, Stoner GD, Mehta R, et al. The dietary anticancer agent ellagic acid is a potent inhibitor of
[xviii] Rogerio AP et al. Anti-inflammatory, analgesic and anti-oedematous effects of Lafnoensia pacari extract and ellagic acid. J Pharm Pharmacol. 2006 Sep;58(9):1265-73
[xx] Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH. Alpha-lipoic acid in liver metabolism and disease; Free Radic Biol Med., 24 (6):1023-1039 (1998).